Corbin Jones, PhD (NextGen); William Marzluff, PhD (DNASeq), Michael Topal, PhD (Genotype), Faculty Directors
Piotr Mieczkowski, PhD (NextGen); Laura Livingstone, PhD (DNASeq), Jingchun Luo, MD,MS (Genotype), Facility Directors
Next Generation Sequencing
Provides comprehensive Next-Generation high-throughput sequencing services via eight (8) Illumina Genome Analyzers and a Roche/454 Titanium. Four of these have been upgraded to the HiSeq 2000. Four HiSeq 2000 will be added in August 2010 and a Pacific Biosciences SMRT DNA sequencing system in Fall 2010.
High Throughput Genotyping The component offers an array of SNP Genotyping services including:
TaqMan standard and custom SNP genotyping: 1 SNP on each sample at a time.
GoldenGate custom SNP genotyping: from 96 to 1,536 SNPs on each sample at a time.
Select Infinium custom panels: From 3,000 to 200,000 SNPs.
Whole Genome Genotyping from 300,000 to 1,200,000 SNPs. Human copy number analysis: DNA copy number variations (CNVs) and loss of heterozygosity (LOH) analysis using the Illumina Infinium Genotyping BeadChips.