Last Updated: 3/23/2010

Joel E Tepper, M.D.

Hector MacLean Distinguished Professor
Clinical Research
Radiation Oncology

Clinical Interests
Gastrointestinal cancer
Soft tissue sarcomas
Radiation therapy treatment planning











Research Interests
Primary research emphasis has been on the use of combined modality therapy with radiation therapy, surgery and chemotherapy in gastrointestinal cancers. This includes work evaluating the basic mechanism of interactions between radiation and chemotherapeutic agents as well as evaluating these interactions through clinical trials. In addition, continuing work on the use of new image display techniques in radiation therapy.












Recent Accomplishments and Honors
American Society of Clinical Oncology- Board of Directors,
UNC- Berryhill Lecturer
Past-President and Past-Chairman of the Board- American Society for Therapeutic Radiology and Oncology (ASTRO)

Gold Medal- ASTRO

Steering Committee- ASCO/ASTRO/AGA/SSO GI Oncology Conference

Principle Investigator- UNC GI SPORE (Specialized Program of Research Excellence)

Course co-Director- AACR/ASCO Vail Workshop on Clinical Trials

Co-chair- US GI Intergroup (GI Steering Comm)

Co-PI on a GI Intergroup trial of adjuvant chemoradiation therapy in gastric cancer

Paper demonstrating the value of surgical salvage in rectal cancer in a large Intergroup clinical trial cohort- to be published in the Journal of Clinical Oncology

Demonstration of the importance of substaging of rectal cancer for individualization of adjuvant therapy

Early phase studies defining the ability to combine various agents (farnesyl transferase inhibitors, gemcitabine, oxaliplatin) with radiation therapy in various tumor types

Design of new radiation parameters for adjuvant treatment of gastric cancer and its implementation in the new Intergroup gastric adjuvant trial












Training
MIT- BSEE- 1968

Washington University School of Medicine, St. Louis, MO M.D.1972 Medicine

Residency- Radiation Oncology- Mass Gen Hosp, Boston

Board Certifications
Radiation Therapy by the American Board of Radiology, 1976











Publications
Stocchi L, Nelson H, Sargent D, O'Connell MJ, Tepper JE, Krook JE, Beart Jr RB, the NCGTG. Surgeon Variability in Rectal Cancer: a US Community and Cooperative Group Report. J Clin Oncol 19(18):3895-3902, 2001.

Blackstock AW, Lightfoot H, Case LD, Tepper JE, Mukherji SK, Mitchell BS, Swarts SG, Hess SM. Tumor Uptake and Elimination of 2',2'-Difluoro-2'-deoxycytidine (Gemcitabine) after Deoxycytidine Kinase Gene Transfer: Correlation with in Vivo Tumor Response. Clin Cancer Res (7): 3263-3268, Oct. 2001.

Smalley SR, Gunderson L, Tepper J, Martenson Jr JA, Minsky B, Willet C, Rich T. Gastric surgical adjuvant radiotherapy consensus report: Rationale and treatment implementation. Int J Rad Oncol Biol Phys, 52(2): 283-293, 2002.

Tepper JE, Gunderson LL. Radiation Treatment Parameters in Adjuvant Postoperative Therapy. Seminars in Rad Onc 12(2):187-195, Apr 2002.

Tepper JE, O'Connell, Niedzwiecki M, Hollis DR, Benson III AB, Cummings B, Gunderson LL, Macdonald JS, Martenson JA, Mayer RJ. Adjuvant Therapy in Rectal Cancer: Analysis of Stage, Sex, and Local Control-Final Report of Intergroup 0114. J Clin Oncol 20(7): 1744-1750, April 2002.

Hahn SM, Bernhard EJ, Regine W, Mohiuddin M, Hallar DG, Stevenson JP, Smith D, Pramanik B, Tepper J, et al. A phase I Trial of the Farnesyltransferase Inhibitor L-778,123 and Radiotherapy for Locally Advanced Lung and Head and Neck Cancer. Clin Cancer Res, 8(5):1065-1072, May 2002.

Chang SX, Cullip TJ, Rosenman JG, Halvorsen P, Tepper JE. Dose optimization via index-dose gradient minimization. Medical Physics 29(6):1130-1146, June 2002.

Gunderson LL, Sargent DJ, Tepper JE, O'Connell MJ, et al. Impact of T and N substage on survival and disease relapse in adjuvant rectal cancer: A pooled analysis. . Int J Rad Oncol Biol Phys, 54(2): 386-396, Oct 2002

Tepper JE, O'Connell M, Hollis D, Niedzwiecki D, Cooke E, Mayer RJ. Analysis of surgical salvage after failure of primary therapy in rectal cancer: results from Intergroup Study 0114. J Clin Oncol 21(19): 3623-3628, Oct 2003.

Meyerhardt JA, Tepper JE, Niedzwiecki D, Hollis DR, Schrag D, at el. Impact of hospital procedure volume on surgical operation and long-term outcomes in high-rish curatively resected rectal cancer: Findings from the Intergroup 0114 Study. J Clin Oncol 22 (1): 166-174, Jan 2004.

Tepper J, Morris D. A model is a model: A decision analysis for rectal cancer. JNCI (96(3): 164-165, Feb 2004.

Meyerhardt JA, Tepper JE, Niedzwiecki D, Hollis DR, McCollum D, at el. Impact of body mass index on outcomes and treaetment-related toxicity in patients with Stage II and III rectal cancer: Findings from Intergroup Trial 0114. J Clin Oncol 22(4): 648-657, Feb 2004.

Tepper JE. Editorial: ASTRO 45th Annual Meeting Presidential Address: Medicine's Arrow, Medicine's Cycle: Lessons for Radiation Oncology. Int J Rad Oncol Biol 59(3): 623-6, 2004.

Tepper JE. Patient selection, realism and randomized clinical trials. J Clin Oncol 22(16):32153217, Aug 2004.

Tepper JE. The Rothenberger/Akbari/Baxter Article Reviewed. Oncology 18(14):1796-1799, Dec 2004

Gunderson LL, Sargent DJ, Tepper JE, Wolmark N, O'Connell MJ, Begovic M, Allmer C, Colangelo L, Smalley SR, Haller DG, Martenson JA, Mayer RJ, Rich TA, Ajani JA, MacDonald JS, Willett CG, Goldberg RM.
Impact of T and N stage and treatment on survival and relapse in adjuvant rectal cancer: a pooled analysis.
J Clin Oncol. 2004 May 15;22(10):1785-96

Horton JK, Tepper JE.
Staging of colorectal cancer: past, present, and future.
Clin Colorectal Cancer. 2005 Jan;4(5):302-12

Baxter NN, Morris AM, Rothenberger DA, Tepper JE.
Impact of preoperative radiation for rectal cancer on subsequent lymph node evaluation: a population-based analysis.
Int J Radiat Oncol Biol Phys. 2005 Feb 1;61(2):426-31.

Baxter NN, Tepper JE, Durham SB, Rothenberger DA, Virnig BA.
Increased risk of rectal cancer after prostate radiation: a population-based study.
Gastroenterology. 2005 Apr;128(4):819-24.

Morris DE, Emami B, Mauch PM, Konski AA, Tao ML, Ng AK, Klein EA, Mohideen N, Hurwitz MD, Fraas BA, Roach M 3rd, Gore EM, Tepper JE.
Evidence-based review of three-dimensional conformal radiotherapy for localized prostate cancer: an ASTRO outcomes initiative.
Int J Radiat Oncol Biol Phys. 2005 May 1;62(1):3-19

Valentini, V, Glimelius, B, Minsky BD, Van Cutsem, E, Bartelink, H, Beets-Tan, Regine, GH, PierreGerard, J, Kosmidis, P, Pahlman, L, Picciocchi, A, Quirke, P, Tepper, JE et al. The multidisciplinary rectal cancer treatment: Main convergences, controversial aspects and investigational areas which support the need for an European Consensus. Radiotherapy and Oncology 76 241-50 2005.

Baxter, NN, Haberman, EB, Tepper JE, et al. Risk of Pelvic Fractures in Older Women Following Pelvic Irradiation. The Journal of the American Medical Association 294 (20):2587-2593 Nov 05

Baxter NN, Habermann EB, Tepper JE, Durham SB, Virnig BA. Risk of pelvic fractures in older women following pelvic irradiation. JAMA. 2005 Nov 23;294(20):2587-93.

Blackstock AW, Mornex F, Partensky C, Descos L, Case LD, Melin SA, Levine EA, Mishra G, Limentani SA, Kachnic LA, Tepper JE. Adjuvant gemcitabine and concurrent radiation for patients with resected pancreatic cancer: a phase II study. Br J Cancer. 2006 Aug 7;95(3):260-5.

Goldberg RM, Niedzwiecki D, Bertagnolli M, Blackstock AW, Tepper JE, Mayer RJ. Cancer and leukemia group B gastrointestinal cancer committee. Clin Cancer Res. 2006 Jun 1;12

Cancer and Leukemia Group B 89901; Ryan DP, Niedzwiecki D, Hollis D, Mediema BE, Wadler S, Tepper JE, Goldberg RM, Mayer RJ. Phase I/II study of preoperative oxaliplatin, fluorouracil, and external-beam radiation therapy in patients with locally advanced rectal cancer: Cancer and Leukemia Group B 89901. J Clin Oncol. 2006 Jun 1;24(16):2557-62

Tepper JE, Sartor CI. Radiation therapy and biologics: a ripe opportunity?Nat Clin ract Oncol. 2006 Sep;3(9):463.

Baxter NN, Hartman LK, Tepper JE, Ricciardi R, Durham SB, Virnig BA. Postoperative Irradiation for Rectal Cancer Increases the Risk of Small Bowel Obstruction After Surgery. Ann Surg. 2007 Apr;245(4):553-559.

Caudle AS, Tepper JE, Calvo BF, Meyers MO, Goyal LK, WG, Kim HJ. Complications associated with neoadjuvant radiotherapy in the multidisciplinary treatment of retroperitoneal sarcomas. Ann Surg Oncol. 2007 Feb;14 (2) :577-82

Stitzenberg KB, Klauber-Demore N, Chang XS, Calvo BF, Ollila DW, Goyal LK, Meyers MO, Kim HJ, Tepper JE, Sartor CI. In vivo intraoperative radiotherapy: a novel approach to radiotherapy for early stage breast cancer. Ann Surg Oncol. 2007 Apr; 14 (4) :1515-6.

O'Dwyer PJ, Eckhardt SG, Haller DG, Tepper J, Ahnen D, Hamilton S, Benson AB 3rd, Rothenberg M, Petrelli N, Lenz HJ, Diasio R, Dubois R, Sargent D, Sloan J, Johnson CD, Comis RL, O'Connell MJ; Gastrointestinal Scientific Leadership Council of the Coalition of Cancer Cooperative Groups. Priorities in Colorectal Cancer Research: Recommendations from the Gastrointestinal Scientific Leadership Council of the Coalition of Cancer Cooperative Groups. J Clin Oncol. 2007 Jun 1;25 (16) :2313-21.

Meropol Neal J, Niedzwiecki D, Shank B, Colacchio TA, Ellerton J, Goldberg RM, and Mayer RJ. Induction Therapy for Poor-Prognosis Anal Canal Carcinoma: A Phase II Study of the Cancer and Leukemia Group B 9281. J Clin Oncol. 2008 June; 26:3229-3234.

Maguire PD, Honaker G, Neal M, Meyerson M, Morris D, Rosenmann J, and Tepper J. A Bridge between Academic and Community Radiation Oncology Treatment Planning. J Oncol Pract; 2007 3:238-241.

Tepper J, Krasna MJ, Niedzwiecki D, Hollis D, Reed CE, Goldberg R, Kiel K, Willett C, Sugarbaker D, and Mayer R. Phase III Trial of Trimodality Therapy With Cisplatin, Fluorouracil, Radiotherapy, and Surgery Compared With Surgery Alone for Esophagel Cancer: J Clin Oncol 2008; 26:1086-1092.

Kuremsky JG, Tepper JE, McLeod HL. Biomarkers for response to neoadjuvant chemoradiation for rectal cancer. Int. J. Radiat. Oncol. Biol. Phys. 2009 Jul 1; 74 (3) : 673-88.:

Tepper JE. Protons and parachutes: J Clin Oncol. 2008; May 20;26 (15): 2436-7. Epub 2008 Apr 28.

Qu P., Chu H, Ibrahim JG, Peacock J, Shen XJ, Tepper J, Sandler RS, Keku TO. Statistical Strategies to Improve the Efficiency of Molecular Studies of Colorectal Cancer Prognosis: British Journal of Cancer 2008; 99(12), 2001-2005.

Goss E, Link MP, Bruinooge SS, Lawrence TS, Tepper JE, Runowicz CD, Schilsky RL; The Impact of the Privacy Rule on Cancer Research: Variations in Attitudes and Application of Regulatory Standards. JClin Oncol. 2009 Aug 20:24 (27): 4014-20







Click here for a list of Publications on PubMed

E-mail: tepper@med.unc.edu
Telephone: (919) 966-0400
FAX: (919) 966-7681
Address: NC Clinical Cancer Ctr Chapel Hill, NC

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