Lawrence B. Marks, M.D.

Professor, Chair
Clinical Research

Clinical Interests
Breast Cancer
Lung Cancer

Research Interests
I am interested in radiation-induced normal tissue reactions and have ongoing studies to consider radiation-induced injury to the lung and heart. I am also interested in the use of computer technology such as three-dimensional radiation treatment planning to improve radiation therapy for patients.

Recent Accomplishments and Honors
Invited lecturer nationally at MD Anderson Hospital, University of Pennsylvania, Thomas Jefferson University, Massachusetts General Hospital, and Yale, among others

Invited lecturer internationally in Vienna, Austria; Tel Aviv, Israel; Buenos Aires, Argentina; Shanghai, China; and Manila, Philippines, among others

Recently awarded grants from the National Institutes of Health (NIH) and Lance Armstrong Foundation to study radiation induced heart and lung injury

Recognized for clinical excellence by Red Book Magazine, Castle Connolly, and Good Housekeeping Magazine

Training
1981, Cooper Union School of Engineering New York, B.S. Bachelor of Engineering in Chemical Engineering
1985, University of Rochester Rochester, NY, M.D. Medicine
1986, Internship, Department of Internal Medicine, Sinai Hospital of Baltimore, Baltimore, MD.

1989, Residency, Department of Radiation Medicine, Massachusetts General Hospital, Boston, MA.

1989-2008: Faculty in Department of Radiation Oncology, Duke University.


Publications
Marks LB, Garst J, Socinski MA, Sibley G, Balckstock AW, Herndon JE, Zhou S, Shafman T, Tisch A, Clough R, Yu X, Turrisi A, Anscher M, Crawford J, Rosenman J. Carboplatin/Paclitaxel or Carboplatin/Vinorelbine followed by acclerated hyperfractionation confromal radiation therapy: report of a prospective phase I dose escalation trial. JCO 22(21): 4329-4340, 2004.

Solin LJ, Fourquet A, Vicini FA, Taylor M, Olivotto IA, haffty B, Strom EA, Pierce LJ, Marks LB, Bartelink H, McNeese MD, Jhingram A, Wai E, Bijker N, Campana F, Hwang WT. Long-term outcome after breast-conservation treatment with radiation for mammographically detected ductal carcinoma in situ of the breast. Cancer 103(6):1137-1146, 2005.

Peters WP, Rosner GL, Vredenburgh JJ, Shpall EJ, Crump M, Richardson PG, Schuster MW, Marks LB, Cirrincione C, Norton L, Henderson IC, Schilsky RL, Hurd DD. Prospective randomized comparison of high-dose chemotherapy with stem-cell support versus intermediate-dose chemotherapy after surgery and adjuvant chemotherapy in women with high-risk primary breast cancer: a report of CALGB 9082, SWOG 9114, and NCIC MA-13. J Clin Oncol , 23(10):2191-2200, 2005.

Kocak Z, Evans ES, Zhou SM, Miller KL, Folz RJ, Shafman TD, Marks LB. Challenges in defining radiation pneumonitis in patients with lung cancer. Int J Radiat Oncol Biol Phys 62:635-638, 2005.

Marks LB, Yu X, Prosnitz RG, Zhou S, Hardenbergh PH, et al. The incidence and functional consequences of RT-associated cardiac perfusion defects. . Int J Radiat Oncol Biol Phys 63:214-223, 2005.

Goldberg H, Prosnitz RG, Olson JA, Marks LB. Definition of post-lumpectomy tumor bed for radiotherapy boost field planning: CT versus surgical clips. . Int J. Radiat Oncol Biol Phys 63(1):209- 213, 2005.

Ahn SJ, Kahn D, Zhou S, Yu X, Hollis D, Shafman TD, Marks LB. Dosimetric and clinical predictors for radiation-induced esophageal injury. Int j Radiat Oncol Biol Phys 61(2):335-347, 2005.

Kelsey CR, Light KL, Marks LB. Patterns of failure after resection of non-small-cell lung cancer: implications for postoperative radiation therapy volumes. Int J Radiat Oncol Biol Phys 65(4):1097-1105, 2006.

Evans ES, Prosnitz RG, Marks LB, et al. Impact of patient-specific factors, irradiated left ventricular volume, and treatment set-up errors on the development of myocardial perfusion defects after radiation therapy for left-sided breast cancer Int J Radiat Oncol Biol Phys 66:1125-1134, 2006.

Mao J, Kocak Z, Marks L, et al. The impact of induction chemotherapy and the associated tumor response on subsequent radiation-related changes in lung function and tumor response. Int J Radiat Oncol Biol Phys 67:1360-1369, 2007.

Anack Y, Meyer J, Marks LB. Association between the incidence of synchronous and metachronous metastases: analysis of SEER data. Oncology 21:828-834, 2007.

Raj KA, Evans ES, Prosnitz RG, Quaranta BP, Hardenbergh PH, Hollis DR, Light KL, Marks LB. Is there an increased risk of local recurrence under the heart block in patens with left-sided breast cancer: Cancer J 12:309-317, 2006.

Marks LB, Ma J: Challenges in the clinical application of advanced technologies to reduce radiation-associated normal tissue injury. Int J Radiat Oncol Biol Phys 69:4-12, 2007.

Prosnitz RG, Hubbs JL, Evans ES, et al. Prospective assessment of radiotherapy-associated cardiac toxicity in breast cancer patients: analysis of data 3 to 6 years after treatment. Cancer 110:1840-1850, 2007.

Zumwalt AC, Marks L, Halperin EC. Integrating gross anatomy into a clinical oncology curriculum: the oncoanatomy course at Duke University School of Medicine. Acad Med 82:469-474, 2007.

Wahl AO, Rademaker A, Kiel KD, et al. Multi-institutional review of repeat irradiation of chest wall and breast for recurrent breast cancer. Int J. Radiat Oncol Biol Phys 70:477-484, 2008.

Fatunase T, Wang Z, Yoo S, et al. Assessment of the residual error in soft tissue setup in patients undergoing partial breast irradiation: results of a prospective study using cone-beam computed tomography. Int J Radiat Oncol Biol Phys, 70:1025-1034, 2008.

Chino JP, Marks LB. Prone positioning causes the heart to be displaced anteriorly within the thorax: implications for breast cancer treatment. Int J Radiat Oncol Biol Phys. 2008 Mar 1;70(3):916-20.

Click here for a list of Publications on PubMed

E-mail: marks@med.unc.edu
Telephone: (919) 966-0400
Address: 1043 NC Clinical Cancer Building Chapel Hill, NC 27599

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