Last Updated: 3/27/2010

Ronald C Chen, MD MPH

Assistant Professor
Cancer Prevention and Control

Clinical Interests
Primary clinical interests are in 1) genitourinary cancers and 2) Cyberknife radiation.

Cyberknife is an exciting new technology, and could represent a more accurate way to deliver radiation because of an ability to ?track? the movement of the tumor (target) during radiation. The University of North Carolina is one of the few academic centers in the United States with a Cyberknife and a clinical trial for prostate cancer patients (4 radiation treatments) is being offered.

Research Interests
Primary research interest involves the long-term outcomes of prostate cancer patients and survivors. This includes bringing new prostate cancer treatments to the clinic, clinical trials, and studying/comparing the efficacy and long-term quality of life effects of current treatments (including surgery and radiation) for prostate cancer.

The long-term quality of life impact of prostate cancer treatments is increasingly recognized as an important consideration in the decision-making process for a patient. For men with localized prostate cancer, most become long-term survivors, but the treatments they chose and received may leave long-lasting quality of life effects and symptoms. Surgery, external beam radiation, and brachytherapy are all accepted standard treatments for localized prostate cancer, but they cause distinctly different short-term and long-term side effects. One of Dr. Chen?s main research interests is in studying the quality of life of prostate cancer survivors, and to bring this information to clinical use by counseling patients prior to choosing treatment.

Recent Accomplishments and Honors
1996 Barry M. Goldwater Scholar
1999 Highest Distinction (equivalent to summa cum laude), University of Kansas
2000 Harvard Medical School PASTEUR Fellow ? Patient-Associated Science: Training, Education, Understanding, and Research
2001 Leopold Schepp Foundation Scholarship
2001 Doris Duke Clinical Research Fellow
2004 Cum laude, Harvard Medical School
2006 Travel grant, American Society for Therapeutic Radiology and Oncology Health Services/Outcomes Research in Oncology Symposium
2007 CaPSURE Scholar
2008 Radiation Therapy Oncology Group (RTOG) Meeting Travel Grant
2009 ASCO Cancer Foundation Merit Award
2009 ASCO/AACR Methods in Clinical Research (Vail Workshop)

Training
B.A., University of Kansas, Lawrence, KS
M.D., Harvard Medical School, Boston, MA
MPH, Harvard School of Public Health, Boston, MA

Intern in Internal Medicine, Massachusetts General Hospital, Boston, MA

Resident in Radiation Oncology, Harvard Radiation Oncology Program, Boston, MA

Chief resident, Harvard Radiation Oncology Program, Boston, MA

Publications
Talcott JA, Manola J, Clark JA, Kaplan I, Beard C, Mitchell SP, Chen RC, O?Leary M, Kantoff PW, D?Amico AV. Time course and predictors of symptoms after primary prostate cancer therapy. J Clin Oncol. 21:3979-86, 2003.

Chen RC, Clark JA, Manola J, Talcott JA. Treatment ?mismatch' in early prostate cancer: do treatment choices take patient quality of life into account? Cancer. 112(1):61-8, 2008.

Chen RC, Lin NU, Golshan M, Harris JR, Bellon JR. Internal mammary nodes in breast cancer: diagnosis and implications for patient management ? a systematic review. J Clin Oncol. 26(30):4981-9, 2008.

Chen RC, Sadetsky N, D?Amico AV, Chen MH, Carroll PR. Maximum versus mono androgen blockade and the risk of PSA recurrence in men with localized or locally-advanced prostate cancer undergoing brachytherapy. Int J Radiat Oncol Biol Phys. 75(1):36-9, 2009.

Chen RC, Clark JA, Talcott JA. Individualizing quality of life outcomes reporting: how localized prostate cancer treatments affect patients with different levels of baseline urinary, bowel and sexual function. J Clin Oncol. 27(24):3916-22, 2009.

Nguyen PL, Chen RC, Clark JA, Cormack RA, Loffredo M, McMahon E, Nguyen AU, Suh WW, Tempany CM, D?Amico AV. Patient-reported quality of life following salvage brachytherapy for radio-recurrent prostate cancer: a prospective phase II study. Brachytherapy. 8(4):345-52, 2009.

Chen RC, Chin MS, Ng AK, Feng Y, Neuberg D, Silver B, Pinkus GS, Stevenson MA, Mauch PM. Early-stage lymphocyte-predominant Hodgkin lymphoma: patient outcomes from a large single-institution series with long follow-up. J Clin Oncol. 28(1):136-41, 2010.

Chen RC, Mamon HJ, Chen YH, Gelman RS, Suh WW, Talcott JA, Clark JW, Hong TS. Patient-reported acute gastrointestinal symptoms during concurrent chemoradiation treatment for rectal cancer. Cancer. (Epub)

Nguyen PL, Chen RC, Hoffman KE, Trofimov A, Efstathiou JA, Coen JJ, Shipley WU, Zietman AL, Talcott JA. Rectal dose-volume histogram parameters are associated with long-term patient-reported gastrointestinal quality of life following conventional and high-dose radiation for prostate cancer: a subgroup analysis of a randomized trial. Int J Radiat Oncol Biol Phys. (Epub)

Click here for a list of Publications on PubMed

E-mail: ronald_chen@med.unc.edu
Telephone: 919-966-0400
Address: 101 Manning Drive, CB 7512 Chapel Hill, NC 27599

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