Last Updated: 6/21/2012

Zhuang (Andrew) Wang, M.D.

Assistant Professor
Molecular Therapeutics

Clinical Interests
GU and GI malignancies

Research Interests
The central theme of our research program is to apply advances from other fields such as chemical engineering, materials science, biomedical engineering and nanotechnology, to the field of oncology.
1. Nanoparticle-based radiosensitizers
2. Nanoparticle chemosensitizers
3. Nanoparticle formulation of "fiorgotten" drugs
4. Biomatrix scaffolds for the ex vivo culturing of primary tumor cells.
5. Combining particle drug delivery with prostate brachytherapy
6. Clinical investigation on nanoparticle formulation of docetaxel

Recent Accomplishments and Honors
2008 ASTRO Resident Poster Recognition Award (Biology)
2008 ASTRO Translational Research Meeting Travel Grant
2009 Triad Golfers Against Cancer Research Grant
2010 ASTRO Junior Faculty Basic Science Research Abstract Award
2010 The National Academies Keck Futures Initiative-Imaging Science Conference
2010 NIH/NCI Paul Calabresi Career Development Award for Clinical Oncology K12
2011 ASTRO Junior Faculty Basic Science Research Abstract Award

Indiana University B.S. 1995-1999 Biology, Biochemistry
Indiana University B.A. 1995-1999 Mathematics
Harvard Medical School M.D. 1999-2004 Medicine
Columbia University College of Physicians and Surgeons, St. Lukes-Roosevelt Hospital Center 2004-2005 Internal Medicine
Harvard Radiation Oncology Program, Harvard Medical School Residency 2005-2009 Radiation Oncology

1. Wang AZ, Farokhzad OC, Zhang LF, Radovic-Moreno A, Gu F, Langer R. Drug delivery system for pharmaceuticals and radiation. International PCT Patent Application No.: PCT/US08/082655 (12/2008).
2. Wang Z, Werner M, Chen R, Byrne J, Karve S, Desimone J. Delivery for brachytherapy and associated methods. International PCT Patent Application No.: PCT/US2010/053357 (10/2010).
3. Wang Z, Pacold M, Werner M, Karve S. Novel Wortmannin Nanoparticles and Uses Thereof. US PCT/US2011/ 61431689 (01/2011).
4. Wang Y, Reid LM, Yamauchi M, Cui C, Wang AZ, Werner M. Biomatrix Scaffolds. PCT/US11/42805 (07/11).
Peer Reviewed Publications:
1. Gu F, Karnik R, Wang A, Alexis F, Levy-Nissenbaum E, Hong S, Langer R, Farokhzad OC. Targeted Nanoparticles for Cancer Therapy. NanoToday, 2007; Vol. 2, No. 3, pg 14-21.
2. Zhang L, Gu FX, Wang AZ, Langer RS, Farokhzad OC. Nanoparticles in Medicine: Therapeutic Applications and Developments. Clinical Pharmacology and Therapeutics, 2007; 83(5):761-9.
3. Wang AZ, Bagalkot V, Vasilliou C, Gu F, Alexis F, Zhang LF, Shaikh M, Yuet K, Cima M, Langer R, Kantoff PW, Bander NH, Jon S, Farokhzad OC. Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates for Combined Prostate Cancer Imaging and Therapy. ChemMedChem. 2008, 3(9):1311-5.
4. Wang AZ, Gu F, Zhang LF, Chan JM, Radovic-Moreno A, Shaikh MR, Farokhzad OC. Biofunctionalized Targeted Nanoparticles for Therapeutic Applications. Expert Opinions on Biological Therapy, 2008; 8(8):1063-70.
5. Gu F, Zhang LF, Teply B, Mann N, Wang A, Radovic-Moreno AF, Langer R, Farokhzad OC. Precise engineering of targeted nanoparticles by using self-assembled biointegrated block co-polymers. Proceedings of the National of Academy of Sciences, 2008, 105(7): 2586-91.
6. Tam WF, Gu TL, Chen J, Lee BH, Bullinger L, Fr?hling S, Wang A, Monti S, Golub TR, Gilliland DG. Oncogenic tyrosine kinases upregulate Id1 in leukemic cells. Blood, 2008, 112(5):1981-92.
7. Zhang L, Chan J, Gu F, Rhee JW, Wang AZ, Radovic-Moreno A, Alexis F, Langer R, Farokhzad OC. Self-assembled lipid-polymer hybrid nanoparticles: A robust drug delivery platform. ACS Nano, 2008, 2(8); 1696-1702.
8. Alexis F, Basto P, Levy-Nissenbaum E, Radovic-Moreno AF, Zhang L, Pridgen E, Wang AZ, Marein SL, Westerhof K, Molnar LK, Farokhzad OC. HER-2-Targeted Nanoparticle-Affibody Bioconjugates for Cancer Therapy. ChemMedChem, 2008, 3(12): 1839-1843
9. Wang AZ, Yuet K, Zhang LF, Gu FX, Huynh-Le M, Radovic-Moreno AF, Kantoff PW, Bander NH, Langer R, Farokhzad OC. ChemRad Nanoparticles: A Novel Multifunctional Nanoparticle Platform for Targeted Delivery of Concurrent Chemoradiation. Nanomedicine, 2010 Apr; 5(3): 361-8. PMCID: PMC2901911
10. Merkel TJ, Jones SW, Herlihy KP, Kersey FR, Shields AR, Napier M, Wang AZ, Bear JE, DeSimone JM. Using Mechano-biological Mimicry to Extend Circulation Times of Red Blood Cell Replicas. Proceedings of the National Academy of Sciences, 2011 Jan 11;108(2):586-91. PMCID: PMC3021010
11. McRee AJ, Cowherd S, Wang AZ, Goldberg RM. Chemoradiation Therapy in the Management of Gastrointestinal Malignancies. Future Oncol. 2011 Mar;7(3): 409-26.
12. Werner ME, Karve S, Sukumar R, Cummings ND, Copp JA, Chen RC, Zhang T, Wang AZ. Folate targeted nanoparticle delivery of chemo- and radio-therapeutics for the treatment of ovarian cancer peritoneal metastasis. Biomaterials, 2011 Aug 16.
13. Werner ME, Copp JA, Karve S, Cummings ND, Sukumar R, Napier M, Chen RC, Cox AD, Wang AZ. Folate-targeted polymeric nanoparticle formulation of docetaxel is an effective molecularly targeted radiosensitizer with efficacy dependent on the timing of radiotherapy. ACS Nano, 2011 Oct 28. [Epub ahead of print].
14. Karve S, Werner ME, Cummings ND, Sukumar R, Wang EC, Zhang YA, Wang AZ. Formulation of diblock polymeric nanoparticles through nanoprecipitation technique. J Vis Exp. 2011 Sep 20;(55)
15. Holmes JA, Wang ZA, Hoffman KE, Hendrix LH, Rosenman JG, Carpenter WR, Godley PA, Chen RC. Is Primary Prostate Cancer Treatment Influenced by Likelihood of Extraprostatic Disease? A Patterns of Care Study Using the Surveillance Epidemiology and End Results Database. Int J Radiat Oncol Biol Phys, 2012 Jan 31.
16. Werner ME, Foote MB, Wang AZ. Chemoradiotherapy of Human Tumors: Novel Approaches from Nanomedicine. Current Pharmaceutical Design, 2012 Feb 28.
17. Di Pasqua AJ, Huckle JE, Kim JK, Chung Y, Wang AZ, Jay M, Lu X. Preparation of Neutron Activatable Holmium Nanoparticles for the Treatment of Ovarian Cancer Metastases. Small, 2012 Feb 2. [Epub ahead of print].
18. Wang AZ, Langer R, Farokhzad OC. Nanoparticle Delivery of Cancer Drugs. Annual Reviews of Medicine. 2012 Jan 26.
19. Karve S, Werner ME, Sukumar R, Cummings ND, Copp JA, Wang EC, Li C, Chen RC, Pacold ME, Wang AZ. Revival of the Abandoned Therapeutic Wortmannin by Nanoparticle Drug Delivery. Proceedings of the National of Academy of Sciences, 2012 Apr 30. [Epub ahead of print].

1. Kim, S.I., Swanson, T.A., Wang, AZ. Underground Clinical Vignettes USMLE Step 2: Surgery. (4th Edition). Lippincott Williams & Wilkins/Wolters Kluwer Health. 2007.

Click here for a list of Publications on PubMed

Telephone: 966-7700
FAX: 966-7768
Address: CB 7512, 100 Manning Drive Chapel Hill, NC 27599

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