Fleming's Two-Stage design

This program generates Fleming's (Fleming, 1982) two-stage designs for Phase II single arm clinical trials that are admissible similar to Jung et al. (2004)

1. Fleming TR (1982). One-sample multiple testing procedure for phase II clinical trials. Biometrics 38: 143-151.
2. Jung SH, Lee TY, Kim KM, George S (2004). Admissible two-stage designs for phase II cancer clinical trials, Statistics in Medicine 23: 561-569.

Type I error rate, α (one-sided):		* * *
Power:		* * *
Response probability of poor drug, p₀:		* * *
Response probability of good drug, p₁:		* * *

Anastasia Ivanova, Ph.D, University of North Carolina at Chapel Hill

Fleming's Two-Stage design