This program generates two-stage designs for testing H
0T ∩ H
0D in a Phase II single arm oncology trial, where H
0T is a null hypothesis about the tumor response rate and and H
0D is a null hypothesis about disease control rate (Ivanova et al., 2012).
Ivanova, A, Monaco, J and Stinchcombe, T. (2012). Efficient designs for phase II oncology trials with ordinal outcome.
Statistics and Its Interface,
5, 463-469.