UNC Lineberger Comprehensive Cancer Center
This program generates two-stage designs for testing H0T ∩ H0D in a Phase II single arm oncology trial, where H0T is a null hypothesis about the tumor response rate and and H0D is a null hypothesis about disease control rate (Ivanova et al., 2012).
Ivanova, A, Monaco, J and Stinchcombe, T. (2012). Efficient designs for phase II oncology trials with ordinal outcome. Statistics and Its Interface, 5, 463-469.
Type I error rate, α (one-sided)
Power of H0T ∩ H0D, 1 - β
Power of H0T, 1 – βT
Power of H0D, 1 – βD
Tumor Response probability of poor drug, p0T
Disease Control probability of poor drug, p0D
Tumor Response probability of good drug, pAT
Disease Control probability of good drug, pAD