Simon's Two-Stage design

This program generates Simon's optimal two-stage designs (Simon, 1989) and admissible designs from Jung et al. (2004) for Phase II single arm clinical trials.

1. Simon R (1989). Controlled Clinical Trials 10: 1-10. Click here to download Simon's (1989) article.
2. Jung SH, Lee TY, Kim KM, George S (2004). Admissible two-stage designs for phase II cancer clinical trials, Statistics in Medicine 23: 561-569.

Type I error rate, α (one-sided):		* * *
Power:		* * *
Response probability of poor drug, p₀:		* * *
Response probability of good drug, p₁:		* * *

Anastasia Ivanova, Ph.D, University of North Carolina at Chapel Hill

Simon's Two-Stage design